Long non-coding RNA HOTAIR: A biomarker and therapeutic target in urological tumors

Pathol Res Pract. 2024 Oct:262:155549. doi: 10.1016/j.prp.2024.155549. Epub 2024 Aug 14.

Abstract

Long non-coding RNAs (lncRNAs) significantly influence gene regulation across epigenetic, transcriptional, and post-transcriptional levels through their interactions with DNA, RNA, and proteins. There is growing evidence of lncRNAs' critical roles in the emergence and progression of various diseases, including urological tumors (UTs), such as cancers of the kidney, bladder, and prostate. Research increasingly links lncRNA dysregulation to diverse cellular processes like invasion, metastasis, apoptosis, and chromatin remodeling. Among these, HOTAIR stands out for its pivotal role in oncogenesis, impacting treatment resistance, cell migration, proliferation, survival, and genomic integrity. This review provides an overview of HOTAIR's functions, its identification, and its biological significance. Furthermore, it delves into HOTAIR's involvement in UTs, underlining its potential as a therapeutic target and biomarker for innovative approaches to treating these cancers.

Keywords: Bladder; HOTAIR; Kidney; Long non coding RNA; Urologic cancer.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor* / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • RNA, Long Noncoding* / genetics
  • Urologic Neoplasms* / genetics
  • Urologic Neoplasms* / pathology

Substances

  • RNA, Long Noncoding
  • HOTAIR long untranslated RNA, human
  • Biomarkers, Tumor