Causal Deep Learning for the Detection of Adverse Drug Reactions: Drug-Induced Acute Kidney Injury as a Case Study

Stud Health Technol Inform. 2024 Aug 22:316:803-807. doi: 10.3233/SHTI240533.

Abstract

Causal Deep/Machine Learning (CDL/CML) is an emerging Artificial Intelligence (AI) paradigm. The combination of causal inference and AI could mine explainable causal relationships between data features, providing useful insights for various applications, e.g. Pharmacovigilance (PV) signal detection upon Real-World Data. The objective of this study is to demonstrate the use of CDL for potential PV signal validation using Electronic Health Records as input data source.

Keywords: causal machine learning; drug safety; electronic health records.

MeSH terms

  • Acute Kidney Injury* / chemically induced
  • Adverse Drug Reaction Reporting Systems
  • Deep Learning*
  • Drug-Related Side Effects and Adverse Reactions*
  • Electronic Health Records*
  • Humans
  • Pharmacovigilance*