In vitro human cell-based models: What can they do and what are their limitations?

Matthias P Lutolf; Milica Radisic; Jeffrey Beekman; Dan Dongeun Huh; Meritxell Huch; Margherita Yayoi Turco; Zeinab Niloofar Tahmasebi Birgani; Dong Gao; Rui Yao; Hang Lin; Takanori Takebe

doi:10.1016/j.cell.2024.07.042

In vitro human cell-based models: What can they do and what are their limitations?

Cell. 2024 Aug 22;187(17):4439-4443. doi: 10.1016/j.cell.2024.07.042.

Authors

Matthias P Lutolf, Milica Radisic, Jeffrey Beekman, Dan Dongeun Huh, Meritxell Huch, Margherita Yayoi Turco, Zeinab Niloofar Tahmasebi Birgani, Dong Gao, Rui Yao, Hang Lin, Takanori Takebe

PMID: 39178827
DOI: 10.1016/j.cell.2024.07.042

Abstract

It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations?

MeSH terms

Cell Culture Techniques / methods
Humans
Models, Biological*

Abstract

MeSH terms

Grants and funding