A FACT about macroH2A removal in immune gene activation

Oliver Meers; Marcus Buschbeck

doi:10.1016/j.molcel.2024.07.028

A FACT about macroH2A removal in immune gene activation

Mol Cell. 2024 Aug 22;84(16):3001-3002. doi: 10.1016/j.molcel.2024.07.028.

Authors

Oliver Meers¹, Marcus Buschbeck²

Affiliations

¹ Program of Applied Epigenetics, Program of Myeloid Neoplasms, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, Badalona, Spain; Doctoral Program in Biomedicine, Universitat de Barcelona, Facultat de Farmàcia i Ciències de l'Alimentació, 08028 Barcelona, Spain.
² Program of Applied Epigenetics, Program of Myeloid Neoplasms, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, Badalona, Spain; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain. Electronic address: [email protected].

PMID: 39178834
DOI: 10.1016/j.molcel.2024.07.028

Abstract

Histone variants contribute to epigenetic regulation in development and disease but require the chaperone machinery for correct deposition. In this issue of Molecular Cell, Ji et al.¹ explain how the chaperone complex FACT removes the histone variant macroH2A1.2 and demonstrate its importance for gene activation in innate immune cells.

MeSH terms

Animals
Epigenesis, Genetic*
Histones* / genetics
Histones* / metabolism
Humans
Immunity, Innate / genetics
Transcriptional Activation

Substances

Histones
macroH2A histone