Intramuscular Botulinum Toxin as an Adjunct to Arthrocentesis with Viscosupplementation in Temporomandibular Disorders: A Proof-of-Concept Case-Control Investigation

Toxins (Basel). 2024 Aug 16;16(8):364. doi: 10.3390/toxins16080364.

Abstract

Background: The reduction in joint load is a potential beneficial factor in managing osteoarthritis of the temporomandibular joint (TMJ). This paper aims to compare the effectiveness of the intramuscular injection of botulinum toxin (BTX-A) as an adjunct to TMJ arthrocentesis plus viscosupplementation with arthrocentesis plus viscosupplementation alone in the management of TMJ osteoarthritis.

Methods: A pilot clinical retrospective study examined TMJ osteoarthritis treatments. Patients were divided into two groups: Group A received BTX-A injections and arthrocentesis with viscosupplementation, while Group B received only arthrocentesis with viscosupplementation. The study assessed outcomes based on mouth opening (MO), pain at rest (PR), pain at mastication (PF), and masticatory efficiency (ME) at various time points (baseline (T0), 1 week (T1), 2 weeks (T2), 3 weeks (T3), and 4 weeks (T4)) up to 2 months after treatment.

Results: The study included two groups, each with five patients. Group A received five weekly sessions of arthrocentesis plus viscosupplementation and a single BTX-A injection during the first arthrocentesis appointment. Group B underwent the five-session protocol of arthrocentesis plus viscosupplementation alone. MO, PF, PR, and ME improved quickly in T2 in both groups, but the improvement was of greater importance over the following weeks and lasted longer in Group A.

Conclusions: Arthrocentesis with viscosupplementation associated with BTX-A was found to be more effective than arthrocentesis alone in improving clinical outcomes. This suggests that patients with TMJ osteoarthritis and myofascial pain may benefit from reduced muscle tone and joint load.

Keywords: arthrocentesis; botulinum toxin; hyaluronic acid; orofacial pain; osteoarthritis; temporomandibular disorders; temporomandibular joint.

MeSH terms

  • Adult
  • Arthrocentesis*
  • Botulinum Toxins, Type A* / administration & dosage
  • Botulinum Toxins, Type A* / therapeutic use
  • Case-Control Studies
  • Combined Modality Therapy
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Osteoarthritis / drug therapy
  • Pilot Projects
  • Proof of Concept Study
  • Retrospective Studies
  • Temporomandibular Joint Disorders* / drug therapy
  • Temporomandibular Joint Disorders* / therapy
  • Treatment Outcome
  • Viscosupplementation* / methods

Substances

  • Botulinum Toxins, Type A

Grants and funding

This research received no external funding.