Research progress on the role of PTEN deletion or mutation in the immune microenvironment of glioblastoma

Front Oncol. 2024 Aug 14:14:1409519. doi: 10.3389/fonc.2024.1409519. eCollection 2024.

Abstract

Recent advances in immunotherapy represent a breakthrough in solid tumor treatment but the existing data indicate that immunotherapy is not effective in improving the survival time of patients with glioblastoma. The tumor microenvironment (TME) exerts a series of inhibitory effects on immune effector cells, which limits the clinical application of immunotherapy. Growing evidence shows that phosphate and tension homology deleted on chromosome ten (PTEN) plays an essential role in TME immunosuppression of glioblastoma. Emerging evidence also indicates that targeting PTEN can improve the anti-tumor immunity in TME and enhance the immunotherapy effect, highlighting the potential of PTEN as a promising therapeutic target. This review summarizes the function and specific upstream and downstream targets of PTEN-associated immune cells in glioblastoma TME, providing potential drug targets and therapeutic options for glioblastoma.

Keywords: PTEN; glioblastoma; immunity; immunosuppressive; tumor microenvironment.

Publication types

  • Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the 2021 hospital-level incubation Project of the Second People’s Hospital of Yibin (Grant number: 2021FY05 and 2021FY16), the Yibin Health and Wellness Medical Research Project (2022YW011, 2023YW009), and the program of Southwest Medical University Higher Education Teaching Research and Reform (JG2022270). The authors declare no conflicts of interests.