Evaluating the efficacy of immunotherapy in gastric cancer: Insights from immune checkpoint inhibitors

World J Gastroenterol. 2024 Aug 28;30(32):3726-3729. doi: 10.3748/wjg.v30.i32.3726.

Abstract

The emergence of immunotherapy, particularly immune checkpoint inhibitors (ICIs), represents a groundbreaking approach to treating gastric cancer (GC). However, the prognosis of GC patients receiving ICI treatment is influenced by various factors. This manuscript identified sarcopenia and myosteatosis as inde-pendent prognostic factors impacting the outcomes of GC patients treated with ICIs. Additionally, this study introduced a visual predictive model to estimate the prognosis of GC patients. If confirmed by further studies, this observation could provide valuable insights to propel the advancement of personalized clinical medicine and the integration of precision medicine practices.

Keywords: Gastric cancer; Immune checkpoint inhibitors; Myosteatosis; Prediction model; Sarcopenia.

Publication types

  • Review
  • Editorial

MeSH terms

  • Humans
  • Immune Checkpoint Inhibitors* / adverse effects
  • Immune Checkpoint Inhibitors* / therapeutic use
  • Immunotherapy* / adverse effects
  • Immunotherapy* / methods
  • Precision Medicine / methods
  • Prognosis
  • Sarcopenia / chemically induced
  • Sarcopenia / immunology
  • Stomach Neoplasms* / drug therapy
  • Stomach Neoplasms* / immunology
  • Stomach Neoplasms* / pathology
  • Stomach Neoplasms* / therapy
  • Treatment Outcome

Substances

  • Immune Checkpoint Inhibitors