Catalyst-Free Dearomative Allylboration of Ketones with Benzo[ b]thiophenylmethyl Boronic Acids

J Org Chem. 2024 Sep 20;89(18):13725-13729. doi: 10.1021/acs.joc.4c01367. Epub 2024 Sep 2.

Abstract

A novel approach to the dearomative allylboration of ketones with benzo[b]thiophenylmethyl boronic acids has been developed. By leveraging the inherent reactivity of the boronic acid unit, this process occurs under mild reaction conditions without the need for a catalyst, leading to the efficient formation of homoallylic tertiary alcohols accompanied by the construction of three-dimensional sulfur-containing alicyclic scaffolds in high yields with excellent stereoselectivities.