Pathogenic microorganism DNA high-throughput genetic sequencing to diagnose peritoneal dialysis-associated peritonitis due to Mycobacterium tuberculosis infection

BMC Nephrol. 2024 Sep 3;25(1):290. doi: 10.1186/s12882-024-03727-3.

Abstract

Peritoneal dialysis-associated peritonitis is a serious complication of peritoneal dialysis, and the prevention and treatment of this condition are important for improving the long-term survival and quality of life of patients. However, peritoneal dialysis-associated peritonitis due to Mycobacterium tuberculosis infection is relatively rare and not easily diagnosed. Here, we present a case of peritoneal dialysis-associated peritonitis caused by Mycobacterium tuberculosis identified by pathogenic microbial DNA high-throughput genetic sequencing. This case demonstrates that pathogenic microbial DNA high-throughput genetic sequencing could be used to improve the detection rate of pathogenic microorganisms in patients with complex conditions, thereby allowing for earlier initiation of treatment.

Keywords: Mycobacterium tuberculosis; Pathogenic microorganism DNA high-throughput genetic sequencing (PMseq-DNA); Peritoneal dialysis; Peritoneal dialysis-associated peritonitis.

Publication types

  • Case Reports

MeSH terms

  • DNA, Bacterial* / analysis
  • Female
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis* / genetics
  • Mycobacterium tuberculosis* / isolation & purification
  • Peritoneal Dialysis* / adverse effects
  • Peritonitis / diagnosis
  • Peritonitis / microbiology
  • Peritonitis, Tuberculous* / diagnosis

Substances

  • DNA, Bacterial

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