Cariprazine and clozapine combination for the treatment of psychosis in a young, female patient with schizophrenia: a case report

Anzejs Dmuhovskis; Maris Taube

doi:10.3389/fpsyt.2024.1452980

Cariprazine and clozapine combination for the treatment of psychosis in a young, female patient with schizophrenia: a case report

Front Psychiatry. 2024 Aug 21:15:1452980. doi: 10.3389/fpsyt.2024.1452980. eCollection 2024.

Authors

Anzejs Dmuhovskis^{1

2}, Maris Taube^{1

2

3}

Affiliations

¹ Faculty of Residency, Riga Stradiņš University, Riga, Latvia.
² Department for Depression and Crisis, Riga Center of Psychiatry and Narcology, Riga, Latvia.
³ Department of Psychosomatic Medicine and Psychotherapy, Riga Stradiņš University, Riga, Latvia.

Abstract

The task of a psychiatrist is to select the most appropriate medication or combination of drugs to treat the symptoms of schizophrenia while minimizing the risk of side effects and ensuring the patient achieves the highest level of functioning possible. This is a challenging task as the action of each drug or group of drugs is different. The efficacy of cariprazine, which affects D3 receptors as a D3/D2 receptor partial agonist, has been extensively studied and is one of the first medication choices by practicing psychiatrists when treating patients with negative symptomatology. In this clinical case, we demonstrate the effective and safe treatment of a patient's positive and affective symptoms using a combination of cariprazine, clozapine, and venlafaxine.

Keywords: cariprazine; clozapine; polypharmacy; psychosis; treatment; young female.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.