Adverse prognostic impact of KIT exon 17 mutations despite negative flow cytometric measurable residual disease in pediatric acute myeloid leukemia with RUNX1::RUNX1T1

Shota Kato; Shin-Ichi Tsujimoto; Jun Matsubayashi; Shotaro Iwamoto; Hidefumi Hiramatsu; Yusuke Okuno; Tatsuya Kamitori; Kentaro Ohki; Takao Deguchi; Nobutaka Kiyokawa; Motohiro Kato; Junko Takita; Shiro Tanaka; Souichi Adachi; Daisuke Tomizawa; Norio Shiba

doi:10.3324/haematol.2024.286243

Adverse prognostic impact of KIT exon 17 mutations despite negative flow cytometric measurable residual disease in pediatric acute myeloid leukemia with RUNX1::RUNX1T1

Haematologica. 2025 Jan 1;110(1):251-256. doi: 10.3324/haematol.2024.286243.

Authors

Shota Kato¹, Shin-Ichi Tsujimoto², Jun Matsubayashi³, Shotaro Iwamoto⁴, Hidefumi Hiramatsu⁵, Yusuke Okuno⁶, Tatsuya Kamitori⁵, Kentaro Ohki⁷, Takao Deguchi⁸, Nobutaka Kiyokawa⁷, Motohiro Kato¹, Junko Takita⁵, Shiro Tanaka⁹, Souichi Adachi¹⁰, Daisuke Tomizawa¹¹, Norio Shiba¹²

Affiliations

¹ Department of Pediatrics, Graduate School of Medicine, the University of Tokyo, Tokyo.
² Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama.
³ Center for Clinical Research and Advanced Medicine, Shiga University of Medical Science, Otsu.
⁴ Department of Pediatrics, Graduate School of Medicine Mie University, Tsu.
⁵ Department of Pediatrics, Graduate School of Medicine Kyoto University, Kyoto.
⁶ Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya.
⁷ Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo.
⁸ Division of Cancer Immunodiagnostics, Children's Cancer Center, National Center for Child Health and Development, Tokyo.
⁹ Department of Clinical Biostatistics, Graduate School of Medicine, Kyoto University, Kyoto.
¹⁰ Human Health Science, Graduate School of Medicine Kyoto University, Kyoto, Japan; and.
¹¹ Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo.
¹² Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama. [email protected].

No abstract available

Grants and funding

Funding: This study was supported by a Grant-in-Aid for Scientific Research (KAKEN, grant number JP19K08350 [to NS] and JP21K15870 and JP24K11004 [to ST]) and Exploratory Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and Development (AMED, grant number JP20ck0106634 [to NS], JP17ck0106329 [to SA], JP20ck0106604 [to SA], and JP23ck0106853 [to DT]); the Project Promoting Clinical Trials for Development from AMED (grant number JP21lk0201702 [to ST]); Kawano Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics, a research grant from the Japanese Society of Hematology (to NS); and a research grant from the Takeda Science Foundation (to NS).