Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors

Nicholas Chapman; Mohammed Iqbal; Adam D Walker; Debra Hawes; Tom Belle Davidson; Nathan Robison; Benita Tamrazi; Jianling Ji; Mark D Krieger; Jennifer A Cotter

doi:10.1111/bpa.13297

Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors

Brain Pathol. 2024 Sep 5:e13297. doi: 10.1111/bpa.13297. Online ahead of print.

Authors

Nicholas Chapman¹, Mohammed Iqbal², Adam D Walker³, Debra Hawes^{3

4}, Tom Belle Davidson^{4

5}, Nathan Robison^{4

5}, Benita Tamrazi^{4

6}, Jianling Ji^{3

4}, Mark D Krieger^{1

4}, Jennifer A Cotter^{3

4}

Affiliations

¹ Department of Surgery and Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, California, USA.
² Department of Neurosurgery, University of Texas, Dell Medical School, Austin, Texas, USA.
³ Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
⁴ Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
⁵ Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
⁶ Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.

PMID: 39237118
DOI: 10.1111/bpa.13297

Abstract

Three distinct MN1::BEND2 fusion-positive tumors in pediatric patients. (A) Clinical course for each patient was variable in part due to differences in initial diagnosis. Each patient responded favorably to gross total resection and is stable at last follow-up. (B) Histologic diversity, lack of prominent classical astroblastoma features, and variable immunoexpression of key markers makes microscopic diagnosis challenging.

Keywords: MN1::BEND2 fusion; MN1‐altered; RNA sequencing; astroblastoma; ependymoma; pediatric.

Publication types

Letter