The role of metal ions in stroke: Current evidence and future perspectives

Shaoshuai Wang; Mengzhe Qin; Xiaochong Fan; Chao Jiang; Qingchuan Hou; Ziyi Ye; Xinru Zhang; Yunfan Yang; Jingyu Xiao; Kevin Wallace; Yousef Rastegar-Kashkooli; Qinfeng Peng; Dongqi Jin; Junyang Wang; Menglu Wang; Ruoqi Ding; Jin Tao; Yun Tai Kim; Ujjal K Bhawal; Junmin Wang; Xuemei Chen; Jian Wang

doi:10.1016/j.arr.2024.102498

The role of metal ions in stroke: Current evidence and future perspectives

Ageing Res Rev. 2024 Sep 5:101:102498. doi: 10.1016/j.arr.2024.102498. Online ahead of print.

Authors

Shaoshuai Wang¹, Mengzhe Qin², Xiaochong Fan², Chao Jiang³, Qingchuan Hou⁴, Ziyi Ye⁴, Xinru Zhang⁴, Yunfan Yang⁴, Jingyu Xiao⁴, Kevin Wallace⁵, Yousef Rastegar-Kashkooli⁶, Qinfeng Peng⁴, Dongqi Jin⁴, Junyang Wang⁴, Menglu Wang⁷, Ruoqi Ding⁴, Jin Tao⁴, Yun Tai Kim⁸, Ujjal K Bhawal⁹, Junmin Wang¹⁰, Xuemei Chen¹¹, Jian Wang¹²

Affiliations

¹ Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China; Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China; Non-commissioned Officer School of Army Medical University, Shijiazhuang, Hebei 050000, China.
² Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
³ Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
⁴ Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
⁵ College of Mathematical and Natural Sciences, University of Maryland, College Park, MD 20742, USA.
⁶ Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China; School of International Education, Zhengzhou University, Zhengzhou, Henan 450001, China.
⁷ Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
⁸ Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea; Department of Food Biotechnology, Korea University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.
⁹ Center for Global Health Research, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu 600077, India; Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan.
¹⁰ Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address: [email protected].
¹¹ Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address: [email protected].
¹² Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China; Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address: [email protected].

PMID: 39243890
DOI: 10.1016/j.arr.2024.102498

Abstract

Metal ions play a pivotal role in maintaining optimal brain function within the human body. Nevertheless, the accumulation of these ions can result in irregularities that lead to brain damage and dysfunction. Disruptions of metal ion homeostasis can result in various pathologies, including inflammation, redox dysregulation, and blood-brain barrier disruption. While research on metal ions has chiefly focused on neurodegenerative diseases, little attention has been given to their involvement in the onset and progression of stroke. Recent studies have identified cuproptosis and confirmed ferroptosis as significant factors in stroke pathology, underscoring the importance of metal ions in stroke pathology, including abnormal ion transport, neurotoxicity, blood-brain barrier damage, and cell death. Additionally, it provides an overview of contemporary metal ion chelators and detection techniques, which may offer novel approaches to stroke treatment.

Keywords: Cupreptosis; Ferroptosis; Iron; Neurotoxicity; Stroke.

Publication types

Review