Venous thromboembolism chemoprophylaxis after severe polytrauma: timing and type of prophylaxis matter

James P Byrne; Morgan Schellenberg

doi:10.1007/s00068-024-02651-3

Venous thromboembolism chemoprophylaxis after severe polytrauma: timing and type of prophylaxis matter

Eur J Trauma Emerg Surg. 2024 Dec;50(6):2721-2726. doi: 10.1007/s00068-024-02651-3. Epub 2024 Sep 10.

Authors

James P Byrne¹, Morgan Schellenberg²

Affiliations

¹ Division of Acute Care Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
² Division of Acute Care Surgery, University of Southern California, Los Angeles General Medical Center, Los Angeles, CA, USA. [email protected].

PMID: 39254696
DOI: 10.1007/s00068-024-02651-3

Abstract

In this review, we provide recommendations as well as summarize available data on the optimal time to initiate venous thromboembolism chemoprophylaxis after severe trauma. A general approach to the severe polytrauma patient is provided as well as in-depth reviews of three high-risk injury subgroups: patients with traumatic brain injury, solid organ injury, and pelvic fractures.

Keywords: Chemoprophylaxis; Severe trauma; Traumatic brain injury; VTE prophylaxis; Venous thromboembolism.

Publication types

Review

MeSH terms

Anticoagulants* / therapeutic use
Brain Injuries, Traumatic / complications
Drug Administration Schedule
Humans
Multiple Trauma* / complications
Risk Factors
Time Factors
Venous Thromboembolism* / etiology
Venous Thromboembolism* / prevention & control

Substances

Anticoagulants