Flavonol-Ruthenium Complexes as Antioxidant and Anticancer Agents

ChemMedChem. 2024 Dec 16;19(24):e202400313. doi: 10.1002/cmdc.202400313. Epub 2024 Nov 5.

Abstract

Flavonol-metal complexes can enhance the biological activity of flavonols. Inspired by the potential of ruthenium-based drugs in pharmaceutical applications, seven flavonol-Ru (II) complexes were synthesized to evaluate their biological activities. Among these compounds, compounds 8, 11, and 12 showed potent antioxidant activities. Compound 12 exhibited superior anti-inflammatory activity to natural quercetin, which served as a positive control. This study is the first to report the free radical scavenging abilities and antioxidant activity of flavonol-Ru (II) complexes. Furthermore, compound 12 demonstrated comparable efficacy to 5-FU against human non-small-cell lung cancer cells (A549). These results strongly support the potential of flavonol-Ru (II) agents.

Keywords: Anti-inflammatory; Anticancer; Antioxidant; Flavonol; Flavonol-ruthenium complexes.

MeSH terms

  • A549 Cells
  • Animals
  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Antioxidants* / chemical synthesis
  • Antioxidants* / chemistry
  • Antioxidants* / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Coordination Complexes* / chemical synthesis
  • Coordination Complexes* / chemistry
  • Coordination Complexes* / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor*
  • Flavonols* / chemical synthesis
  • Flavonols* / chemistry
  • Flavonols* / pharmacology
  • Humans
  • Molecular Structure
  • Ruthenium* / chemistry
  • Ruthenium* / pharmacology
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Ruthenium
  • Flavonols
  • Coordination Complexes
  • Antioxidants