The synergistic effects of Korean Red Ginseng and Cervi Parvum Cornu ameliorating FeCl3-induced arterial thrombosis by downregulating ICAM-1 and VCAM-1

Yi-Seong Kwak; Mohammad Amjad Hossain; Ajay Vijayakumar; Chang Won Kang; Chul Park; Sang-Youel Park; Jong-Hoon Kim

doi:10.1016/j.jgr.2024.06.001

The synergistic effects of Korean Red Ginseng and Cervi Parvum Cornu ameliorating FeCl₃-induced arterial thrombosis by downregulating ICAM-1 and VCAM-1

J Ginseng Res. 2024 Sep;48(5):520-523. doi: 10.1016/j.jgr.2024.06.001. Epub 2024 Jun 7.

Authors

Yi-Seong Kwak¹, Mohammad Amjad Hossain², Ajay Vijayakumar², Chang Won Kang², Chul Park², Sang-Youel Park², Jong-Hoon Kim²

Affiliations

¹ R&D Headquarters, Korea Ginseng Corporation, Daejeon, Republic of Korea.
² College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University, Iksan-city, Republic of Korea.

Abstract

In this study, we compared antithrombotic activities of Korean Red Ginseng (KRG) and Cervi Parvum Cornu (CPC) on rats with induced thrombosis. Results indicate that KRG and CPC suppressed the arterial occlusion and the combination of KRG and CPC (KRG + CPC) treatment exhibited a synergistic effect with maximum reduction in thrombosis.

Keywords: Adhesion molecules; Anti-thrombotic effects; Cervi parvum cornu; Korean Red Ginseng; Thrombosis.