Digital Light Processing of Thermoresponsive Hydrogels from Polyproline-Based Star Polypeptides

Small. 2024 Dec;20(49):e2405578. doi: 10.1002/smll.202405578. Epub 2024 Sep 13.

Abstract

The first report of star poly(L-proline) crosslinkers is disclosed for digital light processing 3D printing of thermoresponsive hydrogels. Through chain end functionalization of star poly(L-proline)s with methacryloyl groups, access to high-resolution defined 3D hydrogel structures via digital light processing is achieved through photoinitiated free radical polymerization. Changing the poly(L-proline) molecular weight has a direct influence on both thermoresponsiveness and printability, while shape-morphing behavior can be induced thermally.

Keywords: 3D printing; digital light processing; hydrogels; polypeptides; thermoresponsive.