LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes

Cell Rep. 2024 Sep 24;43(9):114758. doi: 10.1016/j.celrep.2024.114758. Epub 2024 Sep 11.

Abstract

Ethylene signaling has been indicated as a potential positive regulator of plant warm ambient temperature response, but its underlying molecular mechanisms are largely unknown. Here, we show that LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes. We found that the presence of warm ambient temperature activates ethylene signaling through EIN2 and EIN3, leading to an interaction between LHP1 and accumulated EIN2-C to co-regulate a subset of LHP1-bound genes marked by H3K27me3 and H3K4me3 bivalency. Furthermore, we demonstrate that INO80 is recruited to bivalent genes by interacting with EIN2-C and EIN3, promoting H3K4me3 enrichment and facilitating transcriptional activation in response to a warm ambient temperature. Together, our findings illustrate a mechanism wherein ethylene signaling orchestrates LHP1 and INO80 to regulate warm ambient temperature response by activating specific bivalent genes in Arabidopsis.

Keywords: CP: Plants; bivalent chromatin; ethylene signaling; warm ambient temperature.

MeSH terms

  • Arabidopsis Proteins* / genetics
  • Arabidopsis Proteins* / metabolism
  • Arabidopsis* / genetics
  • Arabidopsis* / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Ethylenes* / metabolism
  • Gene Expression Regulation, Plant*
  • Histones / metabolism
  • Receptors, Cell Surface
  • Signal Transduction*
  • Temperature
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Ethylenes
  • Arabidopsis Proteins
  • ethylene
  • Transcription Factors
  • DNA-Binding Proteins
  • Histones
  • EIN3 protein, Arabidopsis
  • EIN2 protein, Arabidopsis
  • Receptors, Cell Surface