Background: Pediatric onset multiple sclerosis (POMS) patients are at risk for cognitive impairment (CI). Nevertheless, the underlying mechanisms and relationship with paramagnetic rim lesions (PRLs) are not fully understood. We aimed to explore CI with clinical and neuroimaging correlates in POMS.
Methods: We analyzed 10 patients with POMS and 16 healthy controls, evaluating cognitive, clinical, and neuroimaging variables.
Results: Fifty percent of POMS had CI and ninety percent had at least one PRL. A higher percentage of PRLs was associated with worse information processing speed performance.
Conclusion: CI is frequent in POMS and may be related to higher PRL percentage.
Keywords: Cognition; Magnetic resonance volumetry; Paramagnetic rim lesions; Pediatric multiple sclerosis.
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