Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial

Scott Stanslaski; Rebekah L S Summers; Lisa Tonder; Ye Tan; Michelle Case; Robert S Raike; Nathan Morelli; Todd M Herrington; Martijn Beudel; Jill L Ostrem; Simon Little; Leonardo Almeida; Adolfo Ramirez-Zamora; Alfonso Fasano; Travis Hassell; Kyle T Mitchell; Elena Moro; Michal Gostkowski; Nagaraja Sarangmat; Helen Bronte-Stewart; ADAPT-PD Investigators

doi:10.1038/s41531-024-00772-5

Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial

NPJ Parkinsons Dis. 2024 Sep 17;10(1):174. doi: 10.1038/s41531-024-00772-5.

Authors

Scott Stanslaski¹, Rebekah L S Summers², Lisa Tonder², Ye Tan², Michelle Case², Robert S Raike², Nathan Morelli², Todd M Herrington³, Martijn Beudel⁴, Jill L Ostrem⁵, Simon Little⁵, Leonardo Almeida⁶, Adolfo Ramirez-Zamora⁷, Alfonso Fasano^{8

9}, Travis Hassell¹⁰, Kyle T Mitchell¹¹, Elena Moro¹², Michal Gostkowski¹³, Nagaraja Sarangmat¹⁴, Helen Bronte-Stewart¹⁵; ADAPT-PD Investigators

Affiliations

¹ Medtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA. [email protected].
² Medtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA.
³ Massachusetts General Hospital, Harvard Medical School, Boston, USA.
⁴ Department of Neurology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
⁵ Department of Neurology, University of California San Francisco, San Francisco, USA.
⁶ Department of Neurology, University of Minnesota, Minneapolis, USA.
⁷ Department of Neurology, Shands at University of Florida, University of Florida, Gainesville, USA.
⁸ Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada.
⁹ Krembil Brain Institute, University of Toronto, Toronto, ON, Canada.
¹⁰ Department of Neurology, Vanderbilt University Medical Center, Nashville, USA.
¹¹ Duke University Movement Disorders Center, Duke University, Durham, USA.
¹² Grenoble Alpes University, Division of Neurology, Grenoble Institute of Neuroscience, CHU of Grenoble, Grenoble, France.
¹³ Center for Neurological Restoration, Cleveland Clinic Foundation, Cleveland, USA.
¹⁴ Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
¹⁵ Department of Neurology and Neurological Sciences, Stanford University, Stanford, USA.

Abstract

Adaptive deep brain stimulation (aDBS) is an emerging advancement in DBS technology; however, local field potential (LFP) signal rate detection sufficient for aDBS algorithms and the methods to set-up aDBS have yet to be defined. Here we summarize sensing data and aDBS programming steps associated with the ongoing Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) pivotal trial (NCT04547712). Sixty-eight patients were enrolled with either subthalamic nucleus or globus pallidus internus DBS leads connected to a Medtronic Percept^TM PC neurostimulator. During the enrollment and screening procedures, a LFP (8-30 Hz, ≥1.2 µVp) control signal was identified by clinicians in 84.8% of patients on medication (65% bilateral signal), and in 92% of patients off medication (78% bilateral signal). The ADAPT-PD trial sensing data indicate a high LFP signal presence in both on and off medication states of these patients, with bilateral signal in the majority, regardless of PD phenotype.