Virus-like particles (VLPs) are self-assembled protein nanoparticles with repetitive antigen epitopes, which can stimulate immune response and do not contain viral genetic materials. VLPs has important research value and application potential in vaccine development, targeted drug delivery and bioengineering materials. In this review, the mechanism of VLPs vaccine induced immune responses is discussed. The existing VLPs expression systems are summarized. The research progress of VLPs vaccine in prevention and treatment of virus infection are summarized. This review provides general reference and guidance for the design and development of antiviral VLPs vaccine.
病毒样颗粒（VLPs）是一类能够自行组装，具有重复抗原表位，能够刺激机体免疫反应且不含病毒遗传物质的蛋白纳米颗粒。在疫苗研发、药物靶向运输和生物工程材料方面VLPs具有重要的研发价值和应用潜力。本研究对VLPs疫苗诱导免疫反应的机制、现有的VLPs表达技术、防治病毒感染等方面的研究进展进行了综述，为VLPs疫苗的设计和研发提供参考。.