Myocarditis Associated With Anti-IgLON5 Autoimmune Disease Following Immune Checkpoint Inhibitor Therapy

James F Howick V; Jasraj Singh; Petar Saric; Leslie T Cooper Jr; John P Bois

doi:10.1016/j.jaccas.2024.102467

Myocarditis Associated With Anti-IgLON5 Autoimmune Disease Following Immune Checkpoint Inhibitor Therapy

JACC Case Rep. 2024 Aug 21;29(16):102467. doi: 10.1016/j.jaccas.2024.102467.

Authors

James F Howick V¹, Jasraj Singh¹, Petar Saric², Leslie T Cooper Jr³, John P Bois²

Affiliations

¹ Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
² Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
³ Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA.

Abstract

Myocarditis is an inflammatory injury of the myocardium. Viral infections are the most common etiology, but less frequently, inflammatory myocardial injury can result from systemic autoimmune diseases. We present the first reported case of myocarditis in a patient with anti-IgLON5 disease.

Keywords: ICI toxicity; anti-IgLON5 disease; autoimmune myocarditis; immune checkpoint inhibitor therapy; inflammatory cardiomyopathy; myocarditis; novel presentation.

Publication types

Case Reports