The prion principle and Alzheimer's disease

Science. 2024 Sep 20;385(6715):1278-1279. doi: 10.1126/science.adq5252. Epub 2024 Sep 19.

Abstract

Similarities to molecular mechanisms underlying prion diseases may help to refine Alzheimer's disease therapies.

MeSH terms

  • Alzheimer Disease* / drug therapy
  • Alzheimer Disease* / metabolism
  • Amyloid beta-Peptides* / chemistry
  • Amyloid beta-Peptides* / metabolism
  • Animals
  • Humans
  • Mice
  • Prion Diseases / metabolism
  • Prion Proteins* / chemistry
  • Prion Proteins* / metabolism
  • Protein Aggregation, Pathological* / metabolism
  • Protein Folding

Substances

  • Amyloid beta-Peptides
  • Prion Proteins