Preferences for albumin use in adult intensive care unit patients with shock: An international survey

Acta Anaesthesiol Scand. 2024 Oct;68(9):1234-1243. doi: 10.1111/aas.14479. Epub 2024 Jun 21.

Abstract

Introduction: Use of albumin is suggested for some patients with shock, but preferences for its use may vary among intensive care unit (ICU) physicians.

Methods: We conducted an international online survey of ICU physicians with 20 questions about their use of albumin and their opinion towards a randomised trial among adults with shock comparing the use versus no use of albumin.

Results: A total of 1248 respondents participated, with a mean response rate of 37%, ranging from 18% to 75% across 21 countries. Respondents mainly worked in mixed ICUs and 92% were specialists in intensive care medicine. The reported use of albumin in general shock varied as 18% reported 'almost never', 22% 'rarely', 34% 'occasionally', 22% 'frequently' and 4% 'almost always' using albumin. In septic shock, 19% reported 'almost never', 22% 'rarely', 29% 'occasionally', 22% 'frequently' and 7% 'almost always' using albumin. Physicians' preferences were more consistent for haemorrhagic- and cardiogenic shock, with more than 45% reporting 'almost never' using albumin. While the reported use of albumin for other purposes than resuscitation was infrequent (40%-85% reported 'almost never' for five other indications), the most frequent other indications were low serum albumin levels and improvement of the efficacy of diuretics. Most respondents (93%) would randomise adult ICU patients with shock to a trial of albumin versus no albumin.

Conclusions: In this international survey, the reported preferences for the use of albumin in adult ICU patients with shock varied considerably among surveyed ICU physicians. The support for a future randomised trial was high.

Keywords: albumin; fluid therapy; intensive care unit; shock; survey.

MeSH terms

  • Adult
  • Albumins* / therapeutic use
  • Attitude of Health Personnel
  • Critical Care / methods
  • Female
  • Humans
  • Intensive Care Units*
  • Internationality
  • Male
  • Middle Aged
  • Physicians
  • Randomized Controlled Trials as Topic
  • Shock / drug therapy
  • Shock / therapy
  • Shock, Septic / drug therapy
  • Shock, Septic / therapy
  • Surveys and Questionnaires

Substances

  • Albumins