Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions

Laura M Keighley; Chiemi F Lynch-Sutherland; Lorissa McDougall; Suzan N Almomani; Peter Stockwell; Michael R Eccles; Erin C Macaulay

doi:10.1016/j.placenta.2024.09.010

Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions

Placenta. 2024 Dec:158:10-13. doi: 10.1016/j.placenta.2024.09.010. Epub 2024 Sep 14.

Authors

Laura M Keighley¹, Chiemi F Lynch-Sutherland², Lorissa McDougall³, Suzan N Almomani⁴, Peter Stockwell³, Michael R Eccles⁴, Erin C Macaulay³

Affiliations

¹ Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand. Electronic address: [email protected].
² Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand; Kids Neuroscience Centre, Kids Research, Children's Hospital at Westmead, Sydney, New South Wales, Australia; The Children's Medical Research Institute, Sydney, New South Wales, Australia.
³ Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand.
⁴ Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Level 2, 3A Symonds Street, Auckland, New Zealand.

PMID: 39312864
DOI: 10.1016/j.placenta.2024.09.010

Abstract

Transposable elements (TEs) play a crucial role in placental development and dysfunction. Our study examined TE expression in pre-eclampsia (PE) using RNA-seq datasets. We identified differentially expressed TEs and explored the genomic location of the most significant TEs, investigating their possible regulatory roles. Notably, three TEs overlapped with putative enhancer regions, suggesting a potential regulatory impact on gene expression. These findings highlight the regulatory potential of TEs and their importance in placental development, supporting that TE dysregulation may contribute to PE pathogenesis.

Keywords: Placenta; Placental development; Pre-eclampsia; Transposable elements.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA Transposable Elements* / genetics
Enhancer Elements, Genetic*
Female
Humans
Placenta / metabolism
Pre-Eclampsia* / genetics
Pre-Eclampsia* / metabolism
Pregnancy

Substances

DNA Transposable Elements