Control of tuberal hypothalamic development and its implications in metabolic disorders

Marysia Placzek; Kavitha Chinnaiya; Dong Won Kim; Seth Blackshaw

doi:10.1038/s41574-024-01036-1

Control of tuberal hypothalamic development and its implications in metabolic disorders

Nat Rev Endocrinol. 2024 Sep 23. doi: 10.1038/s41574-024-01036-1. Online ahead of print.

Authors

Marysia Placzek^{1

2

3}, Kavitha Chinnaiya⁴, Dong Won Kim^{5

6}, Seth Blackshaw^{7

8

9

10

11}

Affiliations

¹ School of Biosciences, University of Sheffield, Sheffield, UK. [email protected].
² Bateson Centre, University of Sheffield, Sheffield, UK. [email protected].
³ Neuroscience Institute, University of Sheffield, Sheffield, UK. [email protected].
⁴ School of Biosciences, University of Sheffield, Sheffield, UK.
⁵ Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus, Denmark.
⁶ Department of Biomedicine, Aarhus University, Aarhus, Denmark.
⁷ Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected].
⁸ Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected].
⁹ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected].
¹⁰ Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected].
¹¹ Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected].

PMID: 39313573
DOI: 10.1038/s41574-024-01036-1

Abstract

The tuberal hypothalamus regulates a range of crucial physiological processes, including energy homeostasis and metabolism. In this Review, we explore the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes. Major developmental events are discussed in the context of their effect on the establishment of both functional hypothalamic neuronal circuits and brain-body interfaces that are pivotal to the control of metabolism. Emerging evidence indicates that aberrations in molecular pathways during tuberal hypothalamic development contribute to metabolic dysregulation. Understanding the molecular underpinnings of tuberal hypothalamic development provides a comprehensive view of neurodevelopmental processes and offers a promising avenue for future targeted interventions to prevent and treat metabolic disorders.

Publication types

Review

Abstract

Publication types

Grants and funding