Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort

Zilong Bian; Luopiao Xu; Yuting Wang; Min-Kuang Tsai; David Ta-Wei Chu; Huakang Tu; Chi-Pang Wen; Xifeng Wu

doi:10.3389/fonc.2024.1400893

Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort

Front Oncol. 2024 Sep 9:14:1400893. doi: 10.3389/fonc.2024.1400893. eCollection 2024.

Authors

Zilong Bian¹, Luopiao Xu¹, Yuting Wang¹, Min-Kuang Tsai², David Ta-Wei Chu³, Huakang Tu¹, Chi-Pang Wen⁴, Xifeng Wu^{1

4

5}

Affiliations

¹ Department of Big Data in Health Science School of Public Health, and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
³ MJ Health Management Center, Taipei, Taiwan.
⁴ National Institute for Data Science in Health and Medicine, Zhejiang University, Hangzhou, China.
⁵ School of Medicine and Health Science, George Washington University, Washington DC, United States.

Abstract

Objective: To investigate the specific role of inflammation in the connection between obesity and the overall incidence of cancer.

Methods: A total of 356,554 participants in MJ cohort study were included. Systemic inflammation markers from blood samples and anthropometric measurements were determined using professional instruments. The Cox model was adopted to evaluate the association.

Results: Over a median follow-up of 8.2 years, 9,048 cancer cases were identified. For individual systemic inflammation biomarkers, the overall cancer risk significantly escalated as blood C-reactive protein (CRP) (hazard ratio (HR)=1.036 (1.017-1.054)) and globulin (GLO) (HR=1.128 (1.105-1.152)) levels increased, and as hemoglobin (HEMO) (HR=0.863 (0.842-0.884)), albumin (ALB) (HR=0.846 (0.829-0.863)) and platelets (PLA) (HR=0.842 (0.827-0.858)) levels decreased. For composite indicators, most of them existed a significant relationship to the overall cancer risk. Most indicators were correlated with the overall cancer and obesity-related cancer risk, but there was a reduction of association with non-obesity related cancer risk. Most of indicators mediated the association between anthropometric measurements and overall cancer risk.

Conclusions: Systemic inflammatory state was significantly associated with increased risks of cancer risk. Inflammation biomarkers were found to partly mediate the association between obesity and cancer risk.

Keywords: anthropometric; cancer incidence; cohort; inflammation; obesity.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by Zhejiang Key Laboratory of Intelligent Preventive Medicine (2020E10004), Healthy Zhejiang One Million People Cohort (K20230085), the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (2019R01007), Cancer Center, Zhejiang University and Key Research and Development Program of Zhejiang Province (2020C03002) to XW. The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.