Genome sequence of dengue virus serotype 1 isolated from a pediatric patient enrolled in an Ivermectin trial in Thailand

Preeyanuch Sayboonruan; Adisak Songjaeng; Kwanrutai Chin-Inmanu; Phitchapha Proykhunthod; Dararat Prayongkul; Ranyikar Poraha; Dumrong Mairiang; Keswadee Lapphra; Kulkanya Chokephaibulkit; Nuntaya Punyadee; Panisadee Avirutnan

doi:10.1128/mra.00523-24

Genome sequence of dengue virus serotype 1 isolated from a pediatric patient enrolled in an Ivermectin trial in Thailand

Microbiol Resour Announc. 2024 Nov 12;13(11):e0052324. doi: 10.1128/mra.00523-24. Epub 2024 Sep 24.

Authors

Preeyanuch Sayboonruan^{1

2}, Adisak Songjaeng^{1

2}, Kwanrutai Chin-Inmanu³, Phitchapha Proykhunthod^{1

2}, Dararat Prayongkul^{1

2}, Ranyikar Poraha^{1

2}, Dumrong Mairiang^{1

4}, Keswadee Lapphra⁵, Kulkanya Chokephaibulkit^{5

6}, Nuntaya Punyadee^{1

2}, Panisadee Avirutnan^{1

2

4}

Affiliations

¹ Division of Dengue Hemorrhagic Fever Research, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
² Siriraj Center of Research Excellence in Dengue and Emerging Pathogens, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
³ Division of Medical Bioinformatics, Research Group and Research Network Division, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁴ Molecular Biology of Dengue and Flaviviruses Research Team, Medical Molecular Biotechnology Research Group, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok, Thailand.
⁵ Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁶ Siriraj Institute of Clinical Research (SICRES), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Abstract

We sequenced the genome of dengue virus serotype 1 (DENV1) strain 4101301, isolated from a child with dengue fever in Thailand and cultured in C6/36 mosquito cells. These data are crucial for studying DENV1's genetic diversity, evolution, and epidemiology and advancing the knowledge for developing antiviral drugs and vaccines targeting DENV.

Keywords: clinical trial; dengue fever; dengue virus genome; pediatric patient.