A multi-component synthetic route for 2-pyrazolines via acceptorless dehydrogenation of alcohols using homogeneous Ni(II) catalysts

Prashant Kukreti; Rahul Chauhan; Abhishek Panwar; Kaushik Ghosh

doi:10.1039/d4ob01352b

A multi-component synthetic route for 2-pyrazolines via acceptorless dehydrogenation of alcohols using homogeneous Ni(II) catalysts

Org Biomol Chem. 2024 Oct 23;22(41):8273-8278. doi: 10.1039/d4ob01352b.

Authors

Prashant Kukreti¹, Rahul Chauhan¹, Abhishek Panwar², Kaushik Ghosh¹

Affiliations

¹ Department of Chemistry, Indian Institute of Technology, Roorkee 247667, India. [email protected].
² Department of Chemistry, National Institute of Technology Manipur, Langol-795004, Imphal West, Manipur, India.

PMID: 39318345
DOI: 10.1039/d4ob01352b

Abstract

Herein, we present the first efficient and sustainable multicomponent synthesis (MCS) of 2-pyrazolines using acceptorless dehydrogenation of benzyl alcohols catalysed by nickel(II) catalysts. Two air-stable phosphine free nickel(II) complexes anchored by NNN-type pincer ligands were synthesized and efficiently used in the MCS of 40 distinct pyrazoline derivatives.