Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma

Biochem Biophys Res Commun. 2024 Nov 12:733:150701. doi: 10.1016/j.bbrc.2024.150701. Epub 2024 Sep 14.

Abstract

The sensitivity of currently available screening tools for urothelial carcinoma (UC) remains unsatisfactory particularly at early stages. Hence, we aimed to establish a novel blood-based screening tool for urothelial carcinoma. We measured serum d-amino acid levels in 108 and 192 patients with and without UC individuals in the derivation cohort, and 15 and 25 patients with and without UC in the validation cohort. Serum d-asparagine levels were significantly higher in patients with UC than in those without UC (p < 0.0001). We developed a novel screening equation for the diagnosis of urothelial carcinoma using d-asparagine in serum and estimated the glomerular filtration rate (eGFR). Serum d-asparagine levels adjusted for eGFR exhibited high performance in the diagnosis of UC (AUC-ROC, 0.869; sensitivity, 80.6 %; specificity, 82.7 %), even in early-stage UC (AUC-ROC: 0.859, sensitivity: 83.3 %, specificity: 82.3 %), which were previously misdiagnosed via urinary occult blood or urine cytology. This established strategy combined with urinary occult blood, improves diagnostic ability (sensitivity: 93.7 %, specificity: 70.1 %).

Keywords: Biomarker; Bladder cancer; Liquid biopsy; Urothelial carcinoma; d-amino acid; d-asparagine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Asparagine* / blood
  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / urine
  • Carcinoma, Transitional Cell / blood
  • Carcinoma, Transitional Cell / diagnosis
  • Carcinoma, Transitional Cell / urine
  • Early Detection of Cancer / methods
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Male
  • Middle Aged
  • Sensitivity and Specificity
  • Urinary Bladder Neoplasms / blood
  • Urinary Bladder Neoplasms / diagnosis
  • Urinary Bladder Neoplasms / urine
  • Urologic Neoplasms / blood
  • Urologic Neoplasms / diagnosis
  • Urothelium / metabolism
  • Urothelium / pathology

Substances

  • Asparagine
  • Biomarkers, Tumor