Stereoselective Total Synthesis of Rhodocoranes I and J

Org Lett. 2024 Oct 11;26(40):8453-8456. doi: 10.1021/acs.orglett.4c02764. Epub 2024 Sep 26.

Abstract

We report the stereoselective total synthesis of rhodocoranes I and J in 10 steps and 16.4% overall yield from (S)-limonene. The synthesis was accomplished through the convergent assembly of a highly substituted chiral cyclopentanone and a lithiated furanyl silyl ketene acetal. The requisite cyclopentanone framework was strategically constructed from the chiral pool, (S)-limonene, through a sequence of steps that included a hydroboration/oxidation, ozonolysis, aldol condensation, reduction, and palladium-catalyzed diastereoselective allylic transposition. This study provides a general approach to the synthesis of the rhodocorane family, known for their antibacterial, antifungal, and cytotoxic properties.

MeSH terms

  • Catalysis
  • Cyclohexenes / chemical synthesis
  • Cyclohexenes / chemistry
  • Cyclopentanes* / chemical synthesis
  • Cyclopentanes* / chemistry
  • Limonene / chemical synthesis
  • Limonene / chemistry
  • Limonene / pharmacology
  • Molecular Structure
  • Palladium / chemistry
  • Stereoisomerism
  • Terpenes / chemical synthesis
  • Terpenes / chemistry
  • Terpenes / pharmacology

Substances

  • Cyclopentanes
  • Terpenes
  • cyclopentanone
  • Limonene
  • Cyclohexenes
  • Palladium