Evaluation of antibacterial and antiviral efficacy of volatile organic compounds

J Microorg Control. 2024;29(3):113-119. doi: 10.4265/jmc.29.3_113.

Abstract

This study searched for volatile organic compounds (VOCs)having antibacterial and antiviral efficacy. The antibacterial efficacy of volatilized components was evaluated and (2E,4E)-2,4-hexadienal, α- angelica lactone, 2-cyclohexen-1-one and 2-cyclopenten-1-one were found to inhibit the formation of colonies of Staphylococcus aureus and Escherichia coli. Evaluating the antimicrobial efficacy of the surfaces to which each VOC adhered to, these four compounds were revealed to have antibacterial efficacy (antibacterial activity value (A-value)against S. aureus; ≧2.63, A-value against Klebsiella pneumoniae; >5.07, A-value against E. coli; ≧2.17). Furthermore, (2E,4E)-2,4-hexadienal and α-angelica lactone were found to have antiviral efficacy against Influenza A virus (H1N1)and Feline calicivirus on the cotton cloths to which it adheres to (antiviral activity value (R-value)against Influenza A virus; >2.94, R-value against Feline calicivirus; ≧2.31). Using these components, it might be possible to develop antimicrobial products that exhibit antibacterial and antiviral efficacy.

Keywords: aldehyde; antibacterial efficacy; antivirus efficacy; ketone; lactone; volatile organic compounds.

MeSH terms

  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Antiviral Agents* / chemistry
  • Antiviral Agents* / pharmacology
  • Calicivirus, Feline / drug effects
  • Escherichia coli / drug effects
  • Influenza A Virus, H1N1 Subtype / drug effects
  • Klebsiella pneumoniae / drug effects
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects
  • Volatile Organic Compounds* / pharmacology

Substances

  • Antiviral Agents
  • Anti-Bacterial Agents
  • Volatile Organic Compounds