Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI

Cancer Res Commun. 2024 Nov 1;4(11):3036-3048. doi: 10.1158/2767-9764.CRC-24-0152.

Abstract

Using matrix-assisted laser desorption/ionization mass spectrometry imaging techniques on a unique cohort of prostate cancer tissues, we highlighted several molecular characteristics of matrix that have potential to act as early predictors of prostate cancer metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Studies
  • Collagen / metabolism
  • Extracellular Matrix Proteins* / metabolism
  • Humans
  • Male
  • Polysaccharides* / analysis
  • Polysaccharides* / metabolism
  • Prostatic Neoplasms* / metabolism
  • Prostatic Neoplasms* / pathology
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization* / methods
  • Tissue Array Analysis* / methods

Substances

  • Polysaccharides
  • Extracellular Matrix Proteins
  • Collagen