Multicomponent Approaches to Reduce Multidrug-Resistant Organisms in Critical Care: Determining the Ideal Strategy

Salma AlBahrani; Mustafa Saad; Jaber S Alqahtani; Zainab Almoosa; Mohammed Alabdulla; Mohammed Algezery; Sondos AlShehri; Jaffar A Al-Tawfiq

doi:10.1007/s44197-024-00297-3

Multicomponent Approaches to Reduce Multidrug-Resistant Organisms in Critical Care: Determining the Ideal Strategy

J Epidemiol Glob Health. 2024 Dec;14(4):1371-1380. doi: 10.1007/s44197-024-00297-3. Epub 2024 Sep 30.

Authors

Salma AlBahrani^{1

2}, Mustafa Saad^{3

4}, Jaber S Alqahtani⁵, Zainab Almoosa⁴, Mohammed Alabdulla⁴, Mohammed Algezery⁶, Sondos AlShehri⁷, Jaffar A Al-Tawfiq^{8

9

10

11}

Affiliations

¹ Infectious Disease Unit, Specialty Internal Medicine, King Fahd Military Medical Complex, Dhahran, Saudi Arabia.
² College of medicine-Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
³ Department of Infection Control, Alhasa, Saudi Arabia.
⁴ Infectious Disease Department, Almoosa specialist Hospital, Alhasa, Saudi Arabia.
⁵ Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia.
⁶ Infection control Department, King Fahd Military Medical Complex, Dhahran, Saudi Arabia.
⁷ Quality Department, King Fahd Military Medical Complex, Dhahran, Saudi Arabia.
⁸ Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia. [email protected].
⁹ Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. [email protected].
¹⁰ Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [email protected].
¹¹ Accreditation and Infection Control Division, Quality and Patient Safety Department, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia. [email protected].

Abstract

Although there is ample proof of the advantages of infection prevention and Control (IPC) in acute-care hospitals, there is still some questions about the efficacy of IPC interventions for multidrug-resistant organisms (MDROs), and there is a need for the development of evidence-based practices. No healthcare facility has found a single effective technique to reduce MDRO. However, a multicomponent intervention that included improved barrier protection, chlorhexidine bathing, microbiological monitoring, and staff involvement significantly decreased the likelihood of infection in the patient surroundings with multidrug-resistant organisms. A practical strategy suited to reducing the burden of MDROs and their transmission potential in the critical care unit must be established in light of the global development of AMR. In this review, we summarize key findings of a multicomponent approaches to reduce MDROs in critical care units.

Keywords: Antibiotic use; Antimicrobial resistance; CRE; ESBL; Infection prevention; MDRO; MRSA.

Publication types

Review

MeSH terms

Critical Care* / methods
Cross Infection* / prevention & control
Cross Infection* / transmission
Drug Resistance, Multiple*
Humans
Infection Control* / methods
Intensive Care Units