Abnormal T Cells Function Associated With Intraspinal Cold Abscess Caused by Macrolide-resistant Mycoplasma pneumoniae in a Patient With X-linked Agammaglobulinemia

Ying-Ying Jin; Jing Wu; Fei Ding; Hua Huang; Xue-Mei Xu; Qi-Min Chen; Min-Zhi Yin; Yu-Min Zhong; Yan-Liang Jin

doi:10.1097/INF.0000000000004569

Abnormal T Cells Function Associated With Intraspinal Cold Abscess Caused by Macrolide-resistant Mycoplasma pneumoniae in a Patient With X-linked Agammaglobulinemia

Pediatr Infect Dis J. 2024 Oct 1. doi: 10.1097/INF.0000000000004569. Online ahead of print.

Authors

Ying-Ying Jin^{1

2}, Jing Wu^{2

3}, Fei Ding¹, Hua Huang¹, Xue-Mei Xu¹, Qi-Min Chen⁴, Min-Zhi Yin⁵, Yu-Min Zhong⁶, Yan-Liang Jin¹

Affiliations

¹ From the Department of Rheumatology/Immunology.
² Department of Allergy/Immunology Innovation Team.
³ Department of Institute of Pediatric Translational Medicine.
⁴ Department of Pediatric Surgery.
⁵ Department of Pathology.
⁶ Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

PMID: 39348496
DOI: 10.1097/INF.0000000000004569

Abstract

Intraspinal cold abscesses caused by macrolide-resistant Mycoplasma pneumoniae in patients with X-linked agammaglobulinemia have not yet been described to our knowledge. Here we describe a patient with X-linked agammaglobulinemia who developed an intraspinal cold abscess caused by macrolide-resistant M. pneumoniae . Genetic analysis revealed a hemizygous c.1566 + 1G > C (IVS15 + 1G > C) mutation in BTK gene. The patient showed relatively naive T cells and a significant proliferative defect.