Case report: Cardiac neuroendocrine carcinoma and squamous cell carcinoma treated with MR-guided adaptive stereotactic radiation therapy

Xinru Chen; Julius K Weng; Angela Sobremonte; Belinda M Lee; Neil W Hughes; Mustefa Mohammedsaid; Yao Zhao; Xiaochun Wang; Xiaodong Zhang; Joshua S Niedzielski; Sanjay S Shete; Laurence E Court; Zhongxing Liao; Percy P Lee; Jinzhong Yang

doi:10.3389/fonc.2024.1411474

Case report: Cardiac neuroendocrine carcinoma and squamous cell carcinoma treated with MR-guided adaptive stereotactic radiation therapy

Front Oncol. 2024 Sep 16:14:1411474. doi: 10.3389/fonc.2024.1411474. eCollection 2024.

Authors

Xinru Chen^{1

2}, Julius K Weng³, Angela Sobremonte⁴, Belinda M Lee⁴, Neil W Hughes⁴, Mustefa Mohammedsaid⁴, Yao Zhao¹, Xiaochun Wang^{1

2}, Xiaodong Zhang^{1

2}, Joshua S Niedzielski^{1

2}, Sanjay S Shete^{2

5}, Laurence E Court^{1

2}, Zhongxing Liao³, Percy P Lee⁶, Jinzhong Yang^{1

2}

Affiliations

¹ Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
² The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, United States.
³ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁴ Department of Radiation Therapeutic Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁵ Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁶ Department of Radiation Oncology, City of Hope Orange County, Lennar Foundation Cancer Center, Irvine, CA, United States.

Abstract

We present two cases of cardiac metastases adjacent to the right ventricle in a 55-year-old male and a 61-year-old female, both treated with magnetic resonance (MR)-guided adaptive stereotactic radiation therapy (SBRT). The prescribed regimen was 30Gy delivered in 3 fractions using a 1.5 Tesla magnetic resonance linear accelerator (MR-linac). Patients exhibited favorable tolerance to the treatment, with no observed acute toxicity.

Keywords: MR-Linac; MR-guided radiotherapy; SBRT; cardiac metastasis; cardiac tumor.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported in part by the National Institutes of Health through Research Project Grant R01HL157273-03 and Cancer Center Support (Core) Grant P30016672, start-up funds from MD Anderson Cancer Center, and a grant from the Radiation Oncology Institute (ROI2022-9133).