Validation of an ultrahigh contrast divided subtracted inversion recovery technique using a standard T1 phantom

Mark Bydder; Fadil Ali; Paul Condron; Daniel M Cornfeld; Gil Newburn; Eryn E Kwon; Maryam Tayebi; Miriam Scadeng; Tracy R Melzer; Samantha J Holdsworth; Graeme M Bydder

doi:10.1002/nbm.5269

Validation of an ultrahigh contrast divided subtracted inversion recovery technique using a standard T₁ phantom

NMR Biomed. 2024 Dec;37(12):e5269. doi: 10.1002/nbm.5269. Epub 2024 Oct 2.

Authors

Mark Bydder¹, Fadil Ali², Paul Condron^{1

3}, Daniel M Cornfeld^{1

3}, Gil Newburn¹, Eryn E Kwon^{1

3

4}, Maryam Tayebi^{1

3}, Miriam Scadeng^{3

4}, Tracy R Melzer^{5

6}, Samantha J Holdsworth^{1

3}, Graeme M Bydder^{1

7}

Affiliations

¹ Mātai Medical Research Institute, Tairāwhiti-Gisborne, New Zealand.
² Imaging Institute, Cleveland Clinic, Cleveland, Ohio, USA.
³ Department of Anatomy & Medical Imaging, Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland, New Zealand.
⁴ Auckland Bioengineering Institute, Auckland, New Zealand.
⁵ Department of Medicine, University of Otago, Christchurch, New Zealand.
⁶ New Zealand Brain Research Institute, Christchurch, New Zealand.
⁷ Department of Radiology, University of California San Diego, San Diego, California, USA.

PMID: 39355971
DOI: 10.1002/nbm.5269

Abstract

The divided subtracted inversion recovery (dSIR) is a high T₁ contrast technique that shows changes in white matter in patients with traumatic brain injury and hypoxic injury. The changes can be explained by small differences in T₁; however, to date, there has been no independent validation of the technique using a standard reference. The present study develops the theory of the dSIR signal and performs validation using the NIST/ISMRM T₁ phantom. Non-idealities are explored, including the influence of noise bias and finite repetition time (TR), which leads to the introduction of an optimally efficient TR for inversion recovery acquisitions. Results show excellent agreement with theoretical calculations.

Validation of an ultrahigh contrast divided subtracted inversion recovery technique using a standard T₁ phantom

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