Twin Pregnancy in Patient With Fontan Circulation and Homozygous MTHFR Mutation

Rosalinda Palmieri; Emanuela C D'Angelo; Giulia di Già; Marco Della Porta; Rossella Iuzzolino; Veronica Lisignoli; Maria L Narducci; Anita Romiti; Antonio Lanzone; Gianfranco Butera

doi:10.1016/j.jaccas.2024.102526

Twin Pregnancy in Patient With Fontan Circulation and Homozygous MTHFR Mutation

JACC Case Rep. 2024 Sep 18;29(18):102526. doi: 10.1016/j.jaccas.2024.102526.

Affiliations

¹ Department of Paediatric Cardiology, Cardiac Surgery and Heart Lung Transplantation, Bambino Gesù Hospital and Research Institute, IRCCS, Rome, Italy.
² Cardiovascular Science Department, Agostino Gemelli University Polyclinic, IRCCS, Rome, Italy.
³ Department of Woman and Child Health, Woman Health Area, Agostino Gemelli University Polyclinic, IRCCS, Rome, Italy.

Abstract

Singleton pregnancy in Fontan patients is burdened by a significant maternal cardiovascular and obstetric risk. The cardiac workload in a twin pregnancy is greater and could place Fontan-palliated patients at an increased risk of complications. We report a case of a woman with Fontan circulation and homozygous MTHFR mutation who had a twin pregnancy.

Keywords: congenital heart defect; pediatric surgery; pregnancy.

Publication types

Case Reports