Unraveling the Complexity: A Rare Case of Systemic Sclerosis, Rheumatoid Arthritis, and Systemic Lupus Erythematosus Overlap Syndrome

Cureus. 2024 Sep 1;16(9):e68405. doi: 10.7759/cureus.68405. eCollection 2024 Sep.

Abstract

Overlap syndromes involving systemic sclerosis (SSc), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) are rare and present significant diagnostic and therapeutic challenges. This case report details a 54-year-old female who presented with a constellation of clinical and serological features suggestive of both SSc, RA, and SLE. The patient's clinical course, diagnostic findings, and response to treatment are discussed highlighting the need for a multidisciplinary approach in managing such complex cases.

Keywords: autoimmune diseases; overlap syndrome; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis.

Publication types

  • Case Reports