Synthesis of S-Alkyl Dithiocarbamates via Multicomponent Reaction of Cyclic Sulfonium Salts with CS2 and Amines

Li Yang; Jia Shu; Yun Liu; Yuan-Xin Jin; Si Si Chen; Wei Huang; Xiang-Qin Xu; Long-Yong Xie

doi:10.1021/acs.joc.4c02063

Synthesis of S-Alkyl Dithiocarbamates via Multicomponent Reaction of Cyclic Sulfonium Salts with CS₂ and Amines

J Org Chem. 2024 Oct 18;89(20):15248-15263. doi: 10.1021/acs.joc.4c02063. Epub 2024 Oct 3.

Authors

Li Yang^{1

2}, Jia Shu¹, Yun Liu¹, Yuan-Xin Jin¹, Si Si Chen¹, Wei Huang¹, Xiang-Qin Xu¹, Long-Yong Xie¹

Affiliations

¹ Key Laboratory of Comprehensive Utilization of Advantage Plants Resources of Southern Hunan, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China.
² College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.

PMID: 39360740
DOI: 10.1021/acs.joc.4c02063

Abstract

A convenient and practical method for the synthesis of various S-alkyl dithiocarbamates through three-component reaction of sulfonium salts, CS₂ and amines has been developed. The reaction proceeds efficiently without any catalyst and additive under mild and open-air conditions, making it potential applications in pharmaceutical chemistry and sulfur chemistry.