Current Pharmacotherapy and Nutrition Therapy of Alcohol-Associated Liver Disease

Clin Liver Dis. 2024 Nov;28(4):731-745. doi: 10.1016/j.cld.2024.06.018. Epub 2024 Aug 13.

Abstract

Patients with alcohol-associated liver disease (ALD) consume large amounts of empty calories and are at risk for malnutrition. Malnutrition can present with micro- or macro-nutrient deficiencies. The standard-of-care drug treatment for severe alcohol-associated hepatitis (AH) is corticosteroids. While still in the standard treatment there are limitations in efficacy and certain patients do not respond to treatment (Lille score ≥.45). This article will focus on important concepts related to nutrition and ALD and on recent findings on predicting corticosteroid response and prognosis for AH patients.

Keywords: Alcohol associated hepatitis; Alcohol-associated liver disease; Malnutrition; Non-responders; Nutrition support corticosteroids.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / therapeutic use
  • Hepatitis, Alcoholic / drug therapy
  • Hepatitis, Alcoholic / therapy
  • Humans
  • Liver Diseases, Alcoholic* / therapy
  • Malnutrition* / etiology
  • Malnutrition* / therapy
  • Nutrition Therapy / methods
  • Nutritional Support

Substances

  • Adrenal Cortex Hormones