Expression of ten-eleven translocation 2 and glutathione-S-transferase pi in colorectal cancer patients with and without type 2 diabetes mellitus

Folia Med (Plovdiv). 2024 Jun 30;66(3):370-379. doi: 10.3897/folmed.66.e122713.

Abstract

To highlight possible correlations of type 2 diabetes mellitus (T2DM) with microscopic / macroscopic characteristics of colorectal cancer tissues, along with the expression of Ten-Eleven Translocation 2 (TET2) and glutathione-S-transferase pi (GST-pi) proteins.

Keywords: colorectal cancer diabetes mellitus epigenetics glutathione S-transferase pi TET2 protein type 2.

MeSH terms

  • Adult
  • Aged
  • Colorectal Neoplasms* / metabolism
  • Colorectal Neoplasms* / pathology
  • DNA-Binding Proteins* / metabolism
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / metabolism
  • Dioxygenases* / metabolism
  • Female
  • Glutathione S-Transferase pi* / genetics
  • Glutathione S-Transferase pi* / metabolism
  • Humans
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins* / genetics
  • Proto-Oncogene Proteins* / metabolism

Substances

  • Glutathione S-Transferase pi
  • Dioxygenases
  • DNA-Binding Proteins
  • TET2 protein, human
  • Proto-Oncogene Proteins