Outcomes Associated with Healthcare-Associated Respiratory Syncytial Virus in Children's Hospitals

Lisa Saiman; Susan E Coffin; Larry K Kociolek; Danielle M Zerr; Aaron M Milstone; Margaret L Aldrich; Celibell Y Vargas; Morgan A Zalot; Megan E Reyna; Amanda Adler; Danielle Koontz; Emily R Egbert; Jassour Alrikaby; Luis Alba; Sonia Gollerkeri; Madelyn Ruggieri; Lyn Finelli; Yoonyoung Choi

doi:10.1093/jpids/piae099

Outcomes Associated with Healthcare-Associated Respiratory Syncytial Virus in Children's Hospitals

J Pediatric Infect Dis Soc. 2024 Nov 27;13(11):594-598. doi: 10.1093/jpids/piae099.

Authors

Lisa Saiman¹, Susan E Coffin², Larry K Kociolek³, Danielle M Zerr⁴, Aaron M Milstone⁵, Margaret L Aldrich⁶, Celibell Y Vargas¹, Morgan A Zalot², Megan E Reyna³, Amanda Adler⁴, Danielle Koontz⁵, Emily R Egbert⁵, Jassour Alrikaby⁶, Luis Alba¹, Sonia Gollerkeri¹, Madelyn Ruggieri⁷, Lyn Finelli⁷, Yoonyoung Choi⁷

Affiliations

¹ Department of Pediatrics, NewYork-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York, USA.
² Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, Perelman School of Medicine at UPenn, Philadelphia, Pennsylvania, USA.
³ Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
⁴ Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.
⁵ Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁶ Department of Pediatrics, Children's Hospital at Montefiore, Bronx, New York, USA.
⁷ Center for Observational and Real-World Evidence, Rahway, New Jersey, USA.

Abstract

To determine if healthcare-associated (HA)-respiratory syncytial virus (RSV) is associated with worse outcomes, this multicenter cohort study studied 26 children with HA-RSV and 78 matched non-HA-RSV patients of whom 58% and 55%, respectively, had ≥2 comorbidities. Overall, 39% of HA-RSV versus 18% of non-HA-RSV patients required respiratory support escalation (adjusted odds ratio (aOR) 5.1, CI95 1.4, 19.1).

Keywords: escalation of respiratory support; healthcare-associated infections; respiratory syncytial virus.

Publication types

Multicenter Study

MeSH terms

Child
Child, Preschool
Cross Infection* / epidemiology
Cross Infection* / virology
Female
Hospitals, Pediatric*
Humans
Infant
Infant, Newborn
Male
Respiratory Syncytial Virus Infections* / epidemiology
Respiratory Syncytial Virus, Human
Retrospective Studies