Cost-utility of sirolimus in the treatment of vascular malformations

Australas J Dermatol. 2024 Dec;65(8):e259-e262. doi: 10.1111/ajd.14369. Epub 2024 Oct 4.

Abstract

Sirolimus is being increasingly employed to manage specific vascular anomalies. We performed an exploratory cost-utility analysis to evaluate sirolimus as a treatment for vascular malformations from the Australian healthcare system perspective. Over a one-year time horizon, sirolimus treatment was associated with an increased expenditure of AU$2832.80 and a gain of 0.08 quality-adjusted life years (QALYs) when compared to supportive care, resulting in an incremental cost-effectiveness ratio of AU$35,410/QALY. By most metrics, sirolimus would be considered a cost-effective treatment for vascular malformations.

Keywords: cost‐effectiveness analysis; cost‐utility analysis; sirolimus; vascular anomalies; vascular malformations.

MeSH terms

  • Australia
  • Cost-Benefit Analysis*
  • Humans
  • Quality-Adjusted Life Years*
  • Sirolimus* / economics
  • Sirolimus* / therapeutic use
  • Vascular Malformations* / drug therapy
  • Vascular Malformations* / economics

Substances

  • Sirolimus