Oral Chronic Graft-versus-Host Disease and Oral Health after Allogeneic Hematopoietic Cell Transplantation - What the Care Team Needs to Know

Transplant Cell Ther. 2024 Sep;30(9S):S548-S558. doi: 10.1016/j.jtct.2024.07.006.

Abstract

Oral chronic graft-versus-host disease (cGVHD) can present with a multitude of clinical signs and is associated with morbidity and lower quality of life. Oral cGVHC may affect the oral mucosa (reticular white striae, erythema, and/or ulcerations), the salivary glands (hyposalivation and/or xerostomia) and the peri-oral soft tissues (fibrosis and trismus). This review provides a practical and concise approach to the diagnosis and management of oral health needs in pediatric and adult alloHCT recipients within the first 2 years post-transplantation.

Keywords: dentist; hyposalivation; oral chronic GVHD; oral hygiene; ulceration; xerostomia.

Publication types

  • Review

MeSH terms

  • Adult
  • Chronic Disease
  • Graft vs Host Disease* / etiology
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Mouth Diseases / etiology
  • Mouth Diseases / therapy
  • Mouth Mucosa / pathology
  • Oral Health*
  • Patient Care Team
  • Quality of Life
  • Transplantation, Homologous / adverse effects