Cytologic and Clinicopathologic Features of Papillary Thyroid Carcinoma with Prominent Hobnail Features on FNAC

Indian J Otolaryngol Head Neck Surg. 2024 Oct;76(5):4885-4888. doi: 10.1007/s12070-024-04824-3. Epub 2024 Jun 21.

Abstract

The hobnail variation of papillary thyroid cancer (PTC) is an uncommon, aggressive variety with hobnail characteristics on more than 30% of the tumour cells. Because of the entity's rarity, the clinical behaviour and pathologic characteristics of these tumours are still unknown. The purpose of this case study was to look at the cytologic, clinical, and pathological aspects of the hobnail variant of PTC, because of its severe clinicopathologic features and poor outcome, the unusual hobnail type of PTC may necessitate more aggressive treatment than traditional PTCs. The cytologic features of the hobnail variety are distinctive, and FNAC specimens can be used to provide a preoperative diagnosis. Diagnostic parameters for proportion of hobnail morphology need to be refined further. More research is needed to understand how detection of this high-risk variation affects clinical treatment.

Keywords: Aggressive variants of papillary thyroid cancer; Hobnail papillary thyroid carcinoma; Hobnail variant; Neck mass; Papillary thyroid cancer; Thyroid cancer.