A diagnosis of Noonan syndrome through routine whole genome sequencing in a child with an intracranial nongerminomatous germ cell tumor

Affiliations

• ¹ Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ² University of Cambridge School of Clinical Medicine, Cambridge, UK.
• ³ Department of Paediatrics, University of Cambridge, Cambridge, UK.
• ⁴ Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK.
• ⁵ Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ⁶ Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ⁷ Department of Radiation Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ⁸ Department of Radiation Oncology, Proton Beam Therapy Centre, University College London Hospital, London, UK.
• ⁹ Department of Neuropathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ¹⁰ East Genomic Laboratory Hub (GLH) Genetics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ¹¹ Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ¹² Medical Research Council Metabolic Diseases Unit, Institute of Metabolic Science Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.
• ¹³ Department of Medical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
• ¹⁴ Department of Pathology, University of Cambridge, Cambridge, UK.