First naturally occurring homoacridone-flavanone dimers from Glycosmis parviflora

Chihiro Ito; Takuya Matsui; Kaname Mamiya; Tian-Shung Wu; Masataka Itoigawa

doi:10.1080/14786419.2024.2412844

First naturally occurring homoacridone-flavanone dimers from Glycosmis parviflora

Nat Prod Res. 2024 Oct 9:1-7. doi: 10.1080/14786419.2024.2412844. Online ahead of print.

Authors

Chihiro Ito¹, Takuya Matsui^{1

2}, Kaname Mamiya¹, Tian-Shung Wu³, Masataka Itoigawa⁴

Affiliations

¹ Faculty of Pharmacy, Meijo University, Nagoya, Japan.
² Department of Physiology, Aichi Medical University, Nagakute, Japan.
³ Department of Chemistry, National Cheng Kung University, Tainan, Republic of China.
⁴ Tokai Gakuen University, Nagoya, Japan.

PMID: 39381938
DOI: 10.1080/14786419.2024.2412844

Abstract

The structures of flavacitropones A (1)-B (2), which are new homoacridone-flavanone dimers from Glycosmis parviflora (Sims) Kurz. (Rutaceae), were elucidated by spectroscopic studies. Flavacitropone A (1) was evaluated for its biological effects on cytotoxicity and release of histamine and TNF-α in 2,4-dinitrophenyl-human serum albumin-stimulated RBL-2H3 cells (rat basophilic cell line). The compound downregulated TNF-α release, but not histamine release.

Keywords: Glycosmis parviflora (sims) kurz; Rutaceae; flavacitropone; flavanone; homoacridone; inflammation.