Overlapping and Distinct Physical and Biological Phenotypes in Pure Frailty and Obese Frailty

Biosci Rep. 2024 Nov 27;44(11):BSR20240784. doi: 10.1042/BSR20240784.

Abstract

Background: Pure frailty and obese frailty are common types of frailty syndrome. However, the overlapping and distinct characteristics between pure frailty and obese frailty remain unclear. This study aims to reveal the overlapping/distinct physical and biological phenotypes of pure frailty and obese frailty, providing theoretical support for their prevention, diagnosis, and treatment.

Method: Mice were fed either a normal or high-fat diet and assessed at 20 months of age. They were assigned to one of the four groups: control, obesity, pure frailty, and obese frailty. Grip strength, walking speed, physical activity, endurance, and body weight were measured to determine pure frailty and obese frailty. Physical and biological phenotypes were assessed.

Results: Distinct physical phenotypes were observed between pure frailty and obese frailty in terms of body weight, lean mass, fat mass, fat mass in tissue, grip strength, endurance, and physical activity, while walking speed overlapped. In biological phenotypes, levels of Smad2/3, FoxO3a, P62, LAMP-2, and cathepsin L expression were distinct, while AKT, p-AKT, mTOR, p-mTOR, p-Smad2/3, p-FoxO3a, Beclin-1, ATG7, and LC3 overlapped.

Conclusion: Distinct physical phenotypes observed in obese frailty are primarily attributable to the effect of obesity, with further impairment of muscle function resulting from the combined effects of frailty syndromes and obesity. Pure frailty and obese frailty share overlapping biological phenotypes, particularly in the regulation of muscle protein synthesis. Moreover, the interaction between obesity and frailty syndromes gives rise to both overlapping and distinct biological phenotypes, especially in the regulation of specific degradation signaling proteins.

Keywords: frailty; obesity; phenotype.

MeSH terms

  • Animals
  • Body Weight
  • Diet, High-Fat / adverse effects
  • Disease Models, Animal
  • Forkhead Box Protein O3 / genetics
  • Forkhead Box Protein O3 / metabolism
  • Frailty* / metabolism
  • Frailty* / physiopathology
  • Hand Strength
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiopathology
  • Obesity* / metabolism
  • Obesity* / physiopathology
  • Phenotype*
  • Physical Endurance
  • Smad3 Protein / genetics
  • Smad3 Protein / metabolism
  • Walking Speed

Substances

  • Forkhead Box Protein O3
  • FoxO3 protein, mouse
  • Smad3 protein, mouse
  • Smad3 Protein