Mesoporous cerium oxide nanoenzyme for Efficacious impeding tumor and metastasis via Conferring resistance to anoikis

Yunhao Wang; Lei Ding; Juan Feng; Ziguo Lin; Hanlin Yao; Xinyu You; Xiaolong Zhang; Wen Sun; Yang Liu; Peiyuan Wang

doi:10.1016/j.biomaterials.2024.122876

Mesoporous cerium oxide nanoenzyme for Efficacious impeding tumor and metastasis via Conferring resistance to anoikis

Biomaterials. 2024 Oct 8:314:122876. doi: 10.1016/j.biomaterials.2024.122876. Online ahead of print.

Authors

Yunhao Wang¹, Lei Ding², Juan Feng³, Ziguo Lin¹, Hanlin Yao¹, Xinyu You⁴, Xiaolong Zhang⁵, Wen Sun⁶, Yang Liu⁷, Peiyuan Wang⁸

Affiliations

¹ Zhongnan Hospital of Wuhan University, Wuhan, Hubei, PR China.
² Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, PR China; School of Rare Earths, University of Science and Technology of China, Hefei, 230026, PR China.
³ Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, PR China.
⁴ College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, PR China.
⁵ The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR China.
⁶ State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, PR China. Electronic address: [email protected].
⁷ Zhongnan Hospital of Wuhan University, Wuhan, Hubei, PR China. Electronic address: [email protected].
⁸ Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, PR China; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR China. Electronic address: [email protected].

PMID: 39383776
DOI: 10.1016/j.biomaterials.2024.122876

Abstract

Tumor cells can survive when detached from the extracellular matrix or lose cell-to-cell connections, leading to a phenomenon known as anoikis resistance (AR). AR is closely associated with the metastasis and proliferation of tumor cells, enabling them to disseminate, migrate, and invade after detachment. Here, we have investigated a novel composite nanoenzyme comprising mesoporous silica/nano-cerium oxide (MSN-Ce@SP/PEG). This nanoenzyme exhibited satisfactory catalase (CAT) activity, efficiently converting high levels of H₂O₂ within tumor cells into O₂, effectively alleviating tumor hypoxia. Furthermore, MSN-Ce@SP/PEG nanoenzyme demonstrated high peroxidase (POD) activity, elevating reactive oxygen species (ROS) levels and attenuating AR in hepatocellular carcinoma (HCC) cells. The MSN-Ce@SP/PEG nanoenzyme exhibited satisfactory dual bioactivity in CAT and POD and was significantly enhanced under favorable photothermal conditions. Through the synergistic effects of these capabilities, the nanoenzyme disrupted the epithelial-mesenchymal transition (EMT) process in detached HCC cells, ultimately inhibiting the recurrence and metastasis potential of anoikis-resistant HCC cells. This study represents the first report of a novel nanoenzyme based on mesoporous silica/nano-cerium oxide for treating AR in HCC cells, thereby suppressing HCC recurrence and metastasis. The findings of this work offer a pioneering perspective for the development of innovative strategies to prevent the recurrence and metastasis of HCC.

Keywords: Anoikis resistance; Cerium oxide; Epithelial-mesenchymal transition; Metastasis; Nanoenzyme.